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Since the expression of the iron-binding protein ceruloplasmin is reduced in degenerating discs, we performed immunohistochemical staining with specific antibodies in the nucleus pulposus of normal human intervertebral discs and degenerative discs obtained from patients with degenerative intervertebral disc disease DDD. The staining was done on whole sections of non-decalcified discs. The results show that ceruloplasmin is found in the nucleus pulposus of the normal disc.

Interestingly, ceruloplasmin is also found in the granules of the primary and secondary chondrocytes of the intervertebral disc. In degenerating discs with DDD, ceruloplasmin is reduced in the nucleus pulposus, which shows a significant loss of proteoglycans.

There is also a loss of collagen type II, which is partly replaced by collagen type I. Since ceruloplasmin is present in the nucleus pulposus, it may play an important role in collagen degradation and proteoglycan metabolism in the disc. When we think of sci-fi shows, we tend to think of the tropes of the genre. Profile Join date: May 18, About 0 Like Received. Blog Comments. Blog Likes. Forum Posts. Forum Comments.

 
 

 

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